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    • Livestock

    Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

    Multiple neuropeptides are known to regulate water and ion balance in Drosophila melanogaster. Several of these peptides also have other functions in physiology and behavior. Examples are corticotropin-releasing factor-like diuretic hormone (diuretic hormone 44; DH44) and leucokinin (LK), both of which induce fuid secretion by Malpighian tubules (MTs), but also regulate stress responses, feeding, circadian activity and other behaviors. Here, we investigated the functional relations between the LK and DH44 signaling systems. DH44 and LK peptides are only colocalized in a set of abdominal neurosecretory cells (ABLKs). Targeted knockdown of each of these peptides in ABLKs leads to increased resistance to desiccation, starvation and ionic stress. Food ingestion is diminished by knockdown of DH44, but not LK, and water retention is increased by LK knockdown only

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    Informações detalhadas sobre a contribuição

    Projeto

    nEUROSTRESSPEP

    Novel biocontrol agents for insect pests from neuroendocrinology

    Localização
    • Europe
    Autores
    • Shireen Davies
    • Meet Zandawala
    Objetivo
    • Dissemination
    Tipo de ficheiro
    Document
    Tamanho do ficheiro
    4.59 MB
    Publicado em
    17-10-2017
    Idioma original
    English
    Sítio Web oficial do projeto
    nEUROSTRESSPEP
    Licença
    CC BY
    Palavras-chave
    • Diuretic hormone 44
    • factor-like diuretic hormone
    • Leucokinin
    • Stress resistance
    • orticotropin-releasing
    • Peptide hormones

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